| Date | Location | Result | |
| 9/17/22 | Painesville, Ohio | McKendree 38, Lake Erie 37 | Box score |
| Sep 17, 2022 | Tiffin, Ohio | Indianapolis 27, Tiffin 20 | Box score |
| Sep 17, 2022 | Owensboro, Kentucky | Ky. Wesleyan 11, Missouri S&T 6 | Box score |
| Sep 17, 2022 | Columbus, Ohio | Ohio Dominican 31, William Jewell 21 | Box score |
| Sep 17, 2022 | Hillsdale, Michigan | Truman State 21, Hillsdale 13 | Box score |
| Sep 17, 2022 | North Canton, | Quincy 28, Walsh 13 | Box score |
| Sep 17, 2022 | Findlay, Ohio | Findlay 52, Southwest Baptist 35 | Box score |
| Sep 10, 2022 | Bolivar, Missouri | West Florida 49, Southwest Baptist 10 | Box score |
| 9/10/22 | Lebanon, Ill. | Delta State 58, McKendree 34 | Box score |
| Sep 10, 2022 | Des Moines, Iowa | Missouri S&T 17, Drake 14 | Box score |
| Sep 10, 2022 | Rapid City, South Da | Truman State 27, South Dakota Mines 20 | Box score |
| Sep 10, 2022 | Spearfish, South Dak | Black Hills St. 38, William Jewell 19 | Box score |
| Sep 08, 2022 | Quincy, Illinois | Quincy 53, Trinity Int'l 14 | Box score |
| Sep 03, 2022 | Odessa, Texas | Southwest Baptist 41, Tex. Permian Basin 17 | Box score |
| Sep 03, 2022 | Indianapolis, Indian | Indianapolis 57, St. Xavier 0 | Box score |
| Sep 03, 2022 | Kirksville, Missouri | Davenport 20, Truman State 19 | Box score |
| Sep 01, 2022 | Liberty, Missouri | Colorado Mesa 37, William Jewell 14 | Box score |
| Sep 01, 2022 | Marquette, Michigan | McKendree 31, Northern Mich. 24 | Box score |
| Sep 01, 2022 | Rolla, Missouri | South Dakota Mines 43, Missouri S&T 20 | Box score |
| Sep 01, 2022 | Quincy, Illinois | Glenville St. 44, Quincy 15 | Box score |