| Date | Location | Result | |
| 03/24/21 | Evansville, IN | Flagler (Fla.) 70, Truman State 69 | Box score |
| 03/16/21 | Evansville, IN | Truman State 65, Michigan Tech 62 | Box score |
| 03/14/21 | Evansville, IN | Michigan Tech 81, Southern Indiana 69 | Box score |
| 03/14/21 | Evansville, IN | Truman State 82, Ashland 63 | Box score |
| 03/13/21 | Evansville, IN | Southern Indiana 62, Lewis 60 | Box score |
| 03/07/21 | Romeoville, IL | Lewis 76, Drury 71 | Box score |
| 03/06/21 | St. Louis, MO | Lewis 73, Indianapolis 57 | Box score |
| 03/06/21 | St. Louis, MO | Drury 79, Missouri-St. Louis 63 | Box score |
| 03/03/21 | Kirksville, MO | Indianapolis 75, Truman State 73 | Box score |
| 03/03/21 | Lebanon, IL | Lewis 62, McKendree 59 | Box score |
| 03/03/21 | St. Louis, MO | Missouri-St. Louis 84, Lindenwood 78 | Box score |
| 03/03/21 | Bolivar, MO | Drury 99, Southwest Baptist 97 | Box score |
| 02/27/21 | Springfield, IL | Illinois Springfield 80, Missouri S&T 71 | Box score |
| 02/27/21 | Liberty, MO | William Jewell 63, Rockhurst 62 | Box score |
| 02/27/21 | Romeoville, IL | Lewis 81, Maryville 58 | Box score |
| 02/27/21 | Indianapolis, IN | Indianapolis 77, Lindenwood 74 | Box score |
| 02/27/21 | Kirksville, MO | Truman State 79, Southwest Baptist 66 | Box score |
| 02/25/21 | Kirksville, MO | Truman State 81, Rockhurst 76 | Box score |
| 02/25/21 | Quincy, IL | Southwest Baptist 81, Quincy 69 | Box score |
| 02/25/21 | Romeoville, IL | Lewis 74, Missouri S&T 64 | Box score |
| 02/25/21 | Indianapolis, IN | Maryville 60, Indianapolis 56 | Box score |
| 02/25/21 | Lebanon, IL | McKendree 74, Missouri-St. Louis 71 | Box score |
| 02/23/21 | Indianapolis, IN | Indianapolis 69, McKendree 68 | Box score |
| 02/20/21 | Rolla, MO | Indianapolis 73, Missouri S&T 64 | Box score |
| 02/20/21 | Kansas City, MO | Rockhurst 68, Quincy 62 | Box score |
| 02/20/21 | Saint Charles, MO | Lindenwood 116, McKendree 109 | Box score |
| 02/20/21 | Bolivar, MO | Southwest Baptist 73, Illinois Springfield 60 | Box score |
| 02/20/21 | Liberty, MO | Truman State 76, William Jewell 70 | Box score |
| 02/18/21 | Liberty, MO | Quincy 74, William Jewell 70 | Box score |
| 02/18/21 | St. Louis, MO | McKendree 77, Maryville 58 | Box score |
| 02/18/21 | Bolivar, MO | Southwest Baptist 64, Lewis 63 | Box score |
| 02/16/21 | Lebanon, IL | McKendree 66, Illinois Springfield 42 | Box score |
| 02/15/21 | Evansville, IN | Truman State 75, Southern Indiana 72 | Box score |
| 02/13/21 | Springfield, IL | William Jewell 73, Illinois Springfield 68 | Box score |
| 02/13/21 | Lebanon, IL | McKendree 77, Missouri S&T 68 | Box score |
| 02/13/21 | Romeoville, IL | Lewis 79, Rockhurst 66 | Box score |
| 02/13/21 | Indianapolis, IN | Southwest Baptist 88, Indianapolis 80 | Box score |
| 02/13/21 | Evansville, IN | Southern Indiana 91, Drury 90 | Box score |
| 02/13/21 | Quincy, IL | Truman State 74, Quincy 68 | Box score |
| 02/11/21 | Lebanon, IL | Drury 82, McKendree 77 | Box score |
| 02/11/21 | Romeoville, IL | Lewis 75, William Jewell 66 | Box score |
| 02/11/21 | Saint Charles, MO | Lindenwood 83, Maryville 69 | Box score |
| 02/11/21 | Indianapolis, IN | Indianapolis 61, Rockhurst 60 | Box score |
| 02/11/21 | Springfield, IL | Truman State 72, Illinois Springfield 63 | Box score |
| 02/10/21 | Evansville, IN | Southern Indiana 86, Quincy 71 | Box score |
| 02/09/21 | Kansas City, MO | Drury 82, Rockhurst 64 | Box score |
| 02/06/21 | Kansas City, MO | Southern Indiana 67, Rockhurst 57 | Box score |
| 02/06/21 | Bolivar, MO | McKendree 77, Southwest Baptist 64 | Box score |
| 02/06/21 | Quincy, IL | Quincy 75, Illinois Springfield 64 | Box score |
| 02/06/21 | Rolla, MO | Lindenwood 89, Missouri S&T 77 | Box score |
| 02/06/21 | Liberty, MO | Indianapolis 68, William Jewell 65 | Box score |
| 02/06/21 | Kirksville, MO | Truman State 73, Lewis 66 | Box score |
| 02/06/21 | Springfield, MO | Drury 78, Missouri-St. Louis 66 | Box score |
| 02/05/21 | Liberty, MO | Southern Indiana 78, William Jewell 71 | Box score |
| 02/04/21 | Springfield, MO | Drury 90, Lindenwood 71 | Box score |
| 02/04/21 | Kirksville, MO | Truman State 79, Indianapolis 67 | Box score |
| 02/04/21 | Rolla, MO | Maryville 70, Missouri S&T 68 | Box score |
| 02/04/21 | Kansas City, MO | McKendree 69, Rockhurst 65 | Box score |
| 02/04/21 | Quincy, IL | Lewis 94, Quincy 75 | Box score |
| 02/04/21 | Bolivar, MO | Missouri-St. Louis 71, Southwest Baptist 65 | Box score |
| 02/02/21 | Liberty, MO | William Jewell 88, Drury 78 | Box score |
| 01/30/21 | Indianapolis, IN | Indianapolis 86, Quincy 78 | Box score |
| 01/30/21 | St. Louis, MO | Maryville 68, Drury 59 | Box score |
| 01/30/21 | Romeoville, IL | Illinois Springfield 78, Lewis 75 | Box score |
| 01/30/21 | St. Louis, MO | Rockhurst 76, Missouri-St. Louis 67 | Box score |
| 01/30/21 | Saint Charles, MO | Lindenwood 91, Southwest Baptist 90 | Box score |
| 01/28/21 | St. Louis, MO | Southwest Baptist 70, Maryville 54 | Box score |
| 01/28/21 | Rolla, MO | Missouri S&T 67, Drury 66 | Box score |
| 01/28/21 | Saint Charles, MO | Rockhurst 95, Lindenwood 76 | Box score |
| 01/28/21 | St. Louis, MO | Missouri-St. Louis 88, William Jewell 83 | Box score |
| 01/28/21 | Indianapolis, IN | Indianapolis 55, Illinois Springfield 43 | Box score |
| 01/26/21 | St. Louis, MO | Missouri-St. Louis 72, Maryville 68 | Box score |
| 01/26/21 | Springfield, MO | Southwest Baptist 81, Drury 46 | Box score |
| 01/23/21 | Bolivar, MO | Southwest Baptist 88, Missouri S&T 61 | Box score |
| 01/23/21 | Quincy, IL | Quincy 75, McKendree 69 | Box score |
| 01/23/21 | Springfield, IL | Southern Indiana 88, Illinois Springfield 69 | Box score |
| 01/23/21 | Kansas City, MO | Rockhurst 67, Maryville 57 | Box score |
| 01/23/21 | Romeoville, IL | Indianapolis 78, Lewis 68 | Box score |
| 01/23/21 | Liberty, MO | William Jewell 81, Lindenwood 78 | Box score |
| 01/21/21 | Quincy, IL | Missouri-St. Louis 78, Quincy 72 | Box score |
| 01/21/21 | Romeoville, IL | Southern Indiana 74, Lewis 65 | Box score |
| 01/21/21 | Liberty, MO | Maryville 58, William Jewell 51 | Box score |
| 01/21/21 | Bolivar, MO | Southwest Baptist 75, Drury 63 | Box score |
| 01/21/21 | Springfield, IL | Illinois Springfield 76, McKendree 53 | Box score |
| 01/19/21 | Springfield, IL | Indianapolis 75, Illinois Springfield 74 | Box score |
| 01/19/21 | Kansas City, MO | Rockhurst 70, William Jewell 59 | Box score |
| 01/16/21 | Rolla, MO | Missouri S&T 68, William Jewell 66 | Box score |
| 01/16/21 | Saint Charles, MO | Lindenwood 93, Quincy 77 | Box score |
| 01/16/21 | Kirksville, MO | Truman State 72, Maryville 47 | Box score |
| 01/16/21 | Evansville, IN | Southern Indiana 80, Indianapolis 75 | Box score |
| 01/16/21 | Springfield, MO | Drury 91, Rockhurst 81 | Box score |
| 01/16/21 | St. Louis, MO | Missouri-St. Louis 78, Illinois Springfield 50 | Box score |
| 01/14/21 | Quincy, IL | Maryville 86, Quincy 75 | Box score |
| 01/14/21 | Springfield, MO | Drury 94, William Jewell 73 | Box score |
| 01/14/21 | Kirksville, MO | Truman State 93, Missouri S&T 56 | Box score |
| 01/14/21 | Indianapolis, IN | Indianapolis 62, Southern Indiana 61 | Box score |
| 01/14/21 | Romeoville, IL | Missouri-St. Louis 69, Lewis 64 | Box score |
| 01/14/21 | Kansas City, MO | Southwest Baptist 72, Rockhurst 59 | Box score |
| 01/14/21 | Springfield, IL | Illinois Springfield 82, Lindenwood 76 | Box score |
| 01/12/21 | Springfield, IL | Illinois Springfield 69, Lewis 54 | Box score |
| 01/12/21 | St. Louis, MO | Missouri-St. Louis 78, Drury 73 | Box score |
| 01/12/21 | Bolivar, MO | Southern Indiana 84, Southwest Baptist 77 | Box score |
| 01/09/21 | St. Louis, MO | Illinois Springfield 86, Maryville 79 | Box score |
| 01/09/21 | Bolivar, MO | Southwest Baptist 74, William Jewell 62 | Box score |
| 01/09/21 | Springfield, MO | Truman State 74, Drury 53 | Box score |
| 01/09/21 | Saint Charles, MO | Lewis 80, Lindenwood 74 | Box score |
| 01/09/21 | Rolla, MO | Quincy 81, Missouri S&T 72 | Box score |
| 01/09/21 | St. Louis, MO | Missouri-St. Louis 77, Indianapolis 56 | Box score |
| 01/07/21 | St. Louis, MO | Lewis 67, Maryville 61 | Box score |
| 01/06/21 | Springfield, MO | Drury 92, McKendree 88 | Box score |
| 01/06/21 | Kirksville, MO | Truman State 82, William Jewell 77 | Box score |
| 01/06/21 | Bolivar, MO | Southwest Baptist 64, Indianapolis 58 | Box score |
| 01/06/21 | Kansas City, MO | Rockhurst 74, Missouri S&T 53 | Box score |
| 01/06/21 | Saint Charles, MO | Lindenwood 85, Illinois Springfield 75 | Box score |
| 01/05/21 | Quincy, IL | Southern Indiana 83, Quincy 77 | Box score |
| 01/04/21 | Lebanon, IL | McKendree 88, Indianapolis 74 | Box score |
| 01/03/21 | Rolla, MO | Illinois Springfield 84, Missouri S&T 78 | Box score |
| 01/03/21 | Quincy, IL | Quincy 83, Indianapolis 73 | Box score |
| 01/03/21 | Liberty, MO | Missouri-St. Louis 65, William Jewell 52 | Box score |
| 01/03/21 | Kansas City, MO | Lewis 73, Rockhurst 47 | Box score |
| 01/03/21 | Kirksville, MO | Truman State 76, Southern Indiana 69 | Box score |
| 01/03/21 | Springfield, MO | Drury 86, Maryville 59 | Box score |
| 01/02/21 | Bolivar, MO | Southwest Baptist 87, Lindenwood 73 | Box score |
| 12/31/20 | St. Louis, MO | Maryville 90, Truman State 83 | Box score |
| 12/20/20 | Saint Charles, MO | Drury 90, Lindenwood 84 | Box score |
| 12/20/20 | Liberty, MO | Missouri S&T 78, William Jewell 74 | Box score |
| 12/20/20 | Kirksville, MO | Truman State 96, Quincy 91 | Box score |
| 12/19/20 | Romeoville, IL | McKendree 70, Lewis 52 | Box score |
| 12/18/20 | Liberty, MO | Southwest Baptist 89, William Jewell 71 | Box score |
| 12/18/20 | St. Louis, MO | Lindenwood 84, Missouri-St. Louis 72 | Box score |
| 12/18/20 | Romeoville, IL | Lewis 78, McKendree 63 | Box score |
| 12/18/20 | Springfield, MO | Missouri S&T 96, Drury 89 | Box score |
| 12/16/20 | Bolivar, MO | Southwest Baptist 91, Rockhurst 83 | Box score |
| 12/15/20 | Indianapolis, IN | Lewis 77, Indianapolis 64 | Box score |
| 12/14/20 | St. Louis, MO | Missouri-St. Louis 71, Southwest Baptist 63 | Box score |
| 12/12/20 | Saint Charles, MO | Truman State 76, Lindenwood 63 | Box score |
| 12/12/20 | Kansas City, MO | Missouri-St. Louis 82, Rockhurst 77 | Box score |
| 12/12/20 | Evansville, IN | Southern Indiana 81, McKendree 70 | Box score |
| 12/12/20 | Rolla, MO | Southwest Baptist 86, Missouri S&T 72 | Box score |
| 12/12/20 | St. Louis, MO | Quincy 91, Maryville 81 | Box score |
| 12/05/20 | St. Louis, MO | Truman State 81, Missouri-St. Louis 69 | Box score |
| 12/05/20 | Quincy, IL | Lindenwood 88, Quincy 74 | Box score |
| 12/05/20 | Springfield, IL | Maryville 61, Illinois Springfield 60 | Box score |
| 12/05/20 | Rolla, MO | Rockhurst 83, Missouri S&T 81 | Box score |
| 12/03/20 | Rolla, MO | McKendree 89, Missouri S&T 86 | Box score |
| 12/03/20 | St. Louis, MO | Lindenwood 73, Maryville 69 | Box score |
| 12/03/20 | St. Louis, MO | Missouri-St. Louis 89, Quincy 64 | Box score |
| 12/03/20 | Kansas City, MO | Rockhurst 74, Illinois Springfield 68 | Box score |
| 11/29/20 | Evansville, IN | Southern Indiana 81, William Jewell 51 | Box score |
| 11/29/20 | St. Louis, MO | Maryville 76, Missouri S&T 67 | Box score |
| 11/29/20 | Romeoville, IL | Lewis 77, Quincy 70 | Box score |
| 11/29/20 | Lebanon, IL | McKendree 87, Rockhurst 75 | Box score |
| 11/29/20 | Indianapolis, IN | Truman State 66, Indianapolis 64 | Box score |
| 11/27/20 | Indianapolis, IN | William Jewell 70, Indianapolis 69 | Box score |
| 11/27/20 | Springfield, IL | Illinois Springfield 89, Quincy 82 | Box score |
| 11/27/20 | Saint Charles, MO | Lindenwood 89, Missouri S&T 70 | Box score |
| 11/27/20 | Evansville, IN | Rockhurst 81, Southern Indiana 70 | Box score |
| 11/27/20 | Romeoville, IL | Truman State 86, Lewis 65 | Box score |